CBC Members Receive NIH Grant

Crop Bioengineering Consortium member Dipali Sashital (Assistant Professor of Biochemistry, Biophysics & Molecular Biology) has received an award from the National Institute of General Medical Sciences for her proposal entitled “Defining CRISPR adaptation and interference mechanisms in E. coli.” This $1.5M, 5-year R01 grant focuses on the fundamental mechanisms of CRISPR–Cas immune systems, the basis for revolutionary biotechnological tools that are actively used by CBC members for crop genome editing. Native CRISPR–Cas systems protect bacteria against their pathogens, allowing bacterial populations to overcome and survive infections. Understanding the fundamentals of these immune systems is vital for understanding how to control bacterial populations, including pathogens that can infect and destroy crop plants, and for developing new tools for crop biotechnology.